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Transplant Therapy for Diabetes
Joan Stephenson, PhD
JAMA. 2000;284:822.
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Ten research centers in North America and Europe will attempt to replicate the recent success of an experimental technique for transplanting insulin-producing islet cells into patients with type 1 diabetes, the National Institutes of Health (NIH) announced last month.
Starting this fall, the Immune Tolerance Network (ITN), an international consortium of clinical researchers who are seeking ways to induce immune tolerance (as in tolerance of the transplanted islet cells), will expand studies of the new technique, known as the "Edmonton protocol." About 40 patients with poorly controlled type 1 diabetes and secondary complications of the disease will receive islet cell transplants.
The procedure will be performed at the University of Alberta in Edmonton, Canada (where the technique was developed), at seven US medical centers, and at centers in Geneva, Switzerland; Glessen, Germany; and Milan, Italy.
The ITN is a 7-year effort led by the National Institute of . . . [Full Text of this Article]
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