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Lung Disease Gene Identified
Joan Stephenson, PhD
JAMA. 2000;284:822.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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A team of researchers has identified a gene linked with an inherited form of a usually fatal lung disorder, primary pulmonary hypertension (PPH), according to new research funded in part by the National Heart, Lung, and Blood Institute (NHLBI).
Researchers had previously narrowed the search for a PPH-associated gene to a region on chromosome 2. In the new work, published in the September issue of the American Journal of Human Genetics, researchers at Columbia University in New York analyzed DNA from families with the disorder and found that nine of 19 of families had mutations in the gene for bone morphogenetic protein receptor 2 (BMPR2), which plays a role in lung development.
The investigators said that their failure to find any of the identified mutations in the BMPR2 gene in 10 of the families suggests that some cases of PPH may be the result . . . [Full Text of this Article]
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