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Interrelationships and Implications

Marc R. Blackman, MD

JAMA. 2000;284:879-881.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Normal aging is associated with a number of subjective and objective alterations in sleep quality,^1-2 as well as with a variety of changes in endocrine-metabolic functions.³ To date, a precise definition of the chronology of age-related changes in sleep patterns and their possible temporal relationships with changes in neuroendocrine function has yet to be elucidated in healthy men or women. Moreover, the possible clinical and functional significance of such sleep-endocrine changes in the elderly are of great medical and societal interest, even though incompletely understood.

Among the most common sleep disturbances detected in aging individuals are decreased deep (stages 3 and 4 or delta) slow wave (SW) sleep and an increased number and duration of nocturnal awakenings; in contrast, effects of aging on rapid eye movement (REM) sleep appear to be more variable and to occur later in life.⁴ Slow wave sleep is thought to be . . . [Full Text of this Article]

Author Affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Md.

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