This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Ms Grabrick and colleagues¹ suggest that the risk of breast cancer from oral contraceptive (OC) use is related to estrogen use. They state, "The amount of estrogen in OCs has decreased from an initial 150 µg to 50 µg or less currently. . . ." However, the original 1960s "pill," Enovid, contained many times that amount of estrogen. I can find no studies on the risk of breast cancer from Enovid use. If the risk is in fact dose-related, that would seem an obvious "natural experiment."

Larry R. Kirkland, MD
Department of Medicine
Emory University School of Medicine
Atlanta, Ga

1. Grabrick DM, Hartmann LC, Cerhan JR, et al. Risk of breast cancer with oral contraceptive use in women with a family history of breast cancer. JAMA. 2000;284:1791-1798. FREE FULL TEXT

To the Editor: The findings of Ms Grabrick and colleagues¹ strengthen the results of previous studies showing that women who have used OCs and have a family history (first degree female relative) of breast cancer may be at higher risk of developing breast cancer themselves. However, because . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Comparison of Hormone Levels in Nipple Aspirate Fluid of Pre- and Postmenopausal Women: Effect of Oral Contraceptives and Hormone Replacement
Chatterton et al.
J. Clin. Endocrinol. Metab. 2005;90:1686-1691.
ABSTRACT | FULL TEXT  

Prophylactic Oophorectomy and Hormone Replacement Therapy: Protection at What Price?
Garber and Hartman
JCO 2004;22:978-980.
FULL TEXT