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A Real Association?

Jonathan M. Zenilman, MD

JAMA. 2001;285:81-83.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Worldwide, cervical cancer is among the 3 most prevalent malignancies in women, with more than 400 000 cases reported in 1998, of which 12 800 were in the United States.¹ The causal relationship between subtypes of human papillomavirus (HPV) and cervical cancer has been firmly established. The epidemiological data are compelling and consistent, most recently from nested case-control studies in Scandinavia that demonstrated HPV in specimens collected before incident cervical intraepithelial neoplasia (CIN).^2-3

However, there are still important unanswered questions related to pathogenesis. Human papillomavirus infection is common. In adolescent populations, infection rates as high as 44% to 90% have been observed.^4-6 Recent data strongly suggest that the majority of persons with HPV spontaneously clear the infection without any specific medical intervention. Only a small minority of these infected persons develop cervical dysplasia, and of these, a minority develop invasive carcinomas. Therefore, the involvement of cofactors in the . . . [Full Text of this Article]

Author Affiliation: Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Md.

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