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Mike Mitka

JAMA. 2001;285:1567.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Hormone replacement therapy (HRT) with estrogen and progestin does not alter risk of stroke in postmenopausal women with heart disease, according to a report in Circulation: The Journal of the American Heart Association (2001;103:638).

Researchers with the Heart and Estrogen-Progestin Replacement Study (HERS) found that hormone therapy did not significantly increase or decrease risk of stroke or of transient ischemic attacks (TIAs) in women who received it.

Discovering the therapy's impact on stroke and TIAs was a secondary goal of the HERS trial. The study found that 149 of the 2763 HERS participants had a total of 165 strokes, of which 26 were fatal. By the end of the trial, 7% of the women taking the therapy had had a stroke compared with 5% of those receiving a placebo—not a statistically significant difference.

The researchers cautioned that the HERS findings may not apply to women taking estrogen without . . . [Full Text of this Article]

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