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Immunogenicity of Bivalent AC Polysaccharide Meningococcal Vaccine in Children Aged 6 Through 24 Months
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To the Editor: In a study of the effectiveness of a mass immunization campaign in Quebec against meningococcal disease, De Wals et al1 recently reported on a lack of clinical protection against invasive meningococcal type C infections in children younger than 2 years who were immunized with the polysaccharide meningococcal vaccine. Because of concerns about the efficacy of the vaccine in children younger than 2 years, we evaluated the immunogenicity of this vaccine in children younger than 2 years during the same immunization campaign.
Methods
Patients aged 6 to 24 months, recruited from 9 different public health clinics, were given the bivalent AC polysaccharide meningococcal vaccine (Pasteur Mérieux Connaught, North New York, Ontario). From 6 different lots, each child received 0.5 mL of the vaccine subcutaneously. The research protocol was approved by the Ste-Justine ethics committee and written informed consent was obtained from the parents. Blood samples were obtained before and . . . [Full Text of this Article]
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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The Meningococcal Vaccine -- Public Policy and Individual Choices
Offit and Peter
NEJM 2003;349:2353-2356.
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