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To the Editor: In their Research Letter, Dr Chaisson and colleagues,¹ using data from an ongoing study,² address the uncertainty of the timing of antiretroviral treatment initiation,^3-4 and conclude that both CD4 cell counts and viral load should be considered in deciding when to initiate antiretroviral therapy.

Even though the interpretation of their results in Table 2 appears to be correct, we believe that certain issues related to principles of logistic regression are inadequately addressed. The authors suggest that achieving "reduction of HIV RNA to less than 400 copies/mL on at least 1 occasion within 6 months of starting treatment (initial response)" and "response with no subsequent elevation of HIV RNA level to more than 1000 copies/mL (durable response)" were evaluated using multivariable logistic regression.

Logistic regression using risk factors measured in their original units leads to a less arbitrary and more powerful analysis. The distribution of continuous data into . . . [Full Text of this Article]

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