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Matthew H. Kanzler, MD; Serena Mraz-Gernhard, MD

JAMA. 2001;285:1819-1821.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

With a lack of scientific data, standard of care for treatment of patients with melanoma at the beginning of the 20th century called for extensive mutilating surgery and/or local amputation of involved body areas. In the mid-1900s, aggressive lymph node dissections were popular in an attempt to control metastatic disease despite the lack of scientific data that such procedures did, indeed, affect the survival of patients with melanoma. The treatment of melanoma has changed significantly in the intervening years, and can now be guided by data regarding clinical outcomes. The purpose of this review is to present clinicians with an evidence-based summary of the current literature regarding therapy for primary cutaneous melanoma.

Surgical Margins

The surgical approach to the suspect melanocytic lesion is a 2-step process. The first goal is to establish the diagnosis and obtain microstaging (ie, to determine the tumor thickness and assess . . . [Full Text of this Article]

Author Affiliations: Division of Dermatology, Santa Clara Valley Medical Center, San Jose, Calif (Dr Kanzler) and Department of Dermatology, Stanford University School of Medicine (Drs Kanzler and Mraz-Gernhard), Stanford, Calif.

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