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To the Editor: We previously demonstrated in vivo imaging of cell death in the myocardia of patients with acute myocardial infarction using technetium Tc 99m–labeled annexin-V (^99mTc-p-annexin-V [Apomate], Theseus Imaging, Cambridge, Mass) and nuclear imaging.¹ Because high proliferation and apoptotic indices have been reported in rapidly growing malignant tumors,² information about the extent of apoptosis in the tumor may also provide insight into the tumor's biology and prognosis.

Report of a Case

A 65-year-old man was referred to our hospital for treatment of a tumor of the left ventricle (Figure 1). Prior to surgery, we attempted to visualize apoptosis in the tumor using ^99mTc-p-annexin-V. To localize possible ^99mTc-p-annexin-V uptake, a thallous chloride Tl 201 perfusion scintigram was performed simultaneously using a dual-isotope imaging technique.

Figure appears in full text version. Figure 1. Imaging Studies of the Heart A, Echocardiogram of the heart in short-axis orientation shows a large tumor in the left ventricle originating from the lateral . . . [Full Text of this Article]

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