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Joan C. Marini, MD,PhD

JAMA. 2001;285:1886-1888.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Musculoskeletal disorders such as lumbar disk disease are among the most common conditions for which patients seek medical care. Although clinical studies have provided insights into disease prevalence and clinical management, recent research advances have yielded understanding about the molecular mechanisms that may be involved and the genetic mutations that may contribute to a variety of musculoskeletal and connective tissue disorders.

Members of the collagen protein family are the most abundant structural components of the extracellular matrix of connective tissues.¹ In bone, cartilage, tendon, and skin the collagens are organized into ropelike fibrils, called heterotypic because they are composed of multiple collagen types. Collagen types differ in length and chain composition, but all have in common a triple-helical structure and a primary sequence composed of uninterrupted repeats of the sequence Gly-X-Y, where gly is glycine, X is often proline, and Y is often hydroxyproline. Type II . . . [Full Text of this Article]

Author Affiliation: Section on Connective Tissue Disorders, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.

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