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Sean Hennessy, PharmD,MSCE; Brian L. Strom, MD,MPH

JAMA. 2001;285:1888-1889.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Loss of bone mass accompanies the aging process and increases risk of fracture, particularly in women. The principal sites of osteoporotic fractures are the forearm, vertebral body, and hip.¹ Pharmacological theory² and in vivo³ and animal⁴ model observations have suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may increase bone mineral density, raising the hope that these drugs also may be useful in reducing risk of osteoporotic fractures.

With the publication of the article by van Staa and colleagues⁵ in this issue of THE JOURNAL, there are now at least 7 studies reported in full publication or abstract form that have measured the association between statin use and fracture risk.^5-11 Of these, 6 used observational designs^5-10 and 1 reanalyzed data from a randomized trial that was performed to evaluate cardiovascular end points.¹¹ At first glance, these studies appear inconsistent, with 3 positive studies . . . [Full Text of this Article]

Author Affiliations: Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Agency for Healthcare Research and Quality, Rockville, Md; and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pa.

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