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Chemical Andropause and Amyloid- Peptide

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To the Editor: Estrogen status appears to modify the risk of developing Alzheimer disease (AD).¹ It has recently been proposed that this may be due to the effect of gonadal hormones on amyloid- peptide (A), which is the main neurotoxic component of cerebral amyloid found in AD.^2-4 Furthermore, rising plasma A levels have been found to be associated with incipient AD,⁵ and a genetically linked phenotype of elevated plasma A levels appears to be related to the risk for late-onset AD.⁶ We studied the effect of gonadal hormone withdrawal in men on plasma levels of A^1-40.

Method

We measured plasma levels of testosterone, 17 -estradiol, and A^1-40 in 6 men aged 44 to 83 years who underwent hormonal suppressive therapy for adenocarcinoma of the prostate. For all 6 patients, the regimen was composed of flutamide (250 mg, 3 times daily) and leuprorelin acetate (22.5 mg, intramuscularly, weekly for 12 . . . [Full Text of this Article]

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