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Louisa E. Chapman, MD; Eda T. Bloom, PhD

JAMA. 2001;285:2304-2306.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The remarkable half-century transition of whole organ transplantation from experimental intervention to standard clinical practice has resulted in a growing disparity between the number of persons who could potentially benefit from allotransplants and the availability of transplantable human organs.¹ This disparity inspired initial attempts to explore alternative therapies for organ failure, among them xenotransplantation, which involves the use of living, nonhuman animal tissues in humans.

Prior to the last decade, the US clinical experience with xenotransplantation largely consisted of rare, whole organ transplants. Recipient survival after the xenograft was generally measured in days or weeks. Although animal studies and the early unregulated human trials have not demonstrated whole organ xenograft survival rates high enough to justify proceeding with clinical trials, active preclinical research on whole organ xenografting continues. More promising research also continues regarding the potential role of approaches other than whole . . . [Full Text of this Article]

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Author Affiliations: HIV/AIDS and Retrovirology Branch, Division of AIDS, STD and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Ga (Dr Chapman); Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Md (Dr Bloom).

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