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Translation of Genomic Research Into Health Care
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To the Editor: Drs Collins and McKusick predict that the Human Genome Project will lead to individualized prevention and therapy.1 However, the rate of new gene discoveries seems to be outpacing the ability to use genetic information to benefit health. To close this gap, we see a crucial role for public health research in the 21st century, especially in the following 3 areas.
Epidemiologic Research
Family studies overestimate the penetrance of genetic variants. Population-based studies are needed to assess prevalence of gene variants, associated disease risks, and gene-environment interactions.2 One example is the Atherosclerosis Risk in Communities Study, which is used to measure interactions between genetic variants and environmental risk factors for cardiovascular disease.3
Policy and Communication Research
Appropriate policies for the use of genetic tests should be based on sound scientific data, as well as ethical, legal, and social considerations. Public health research provides the foundation for developing such policies. For . . . [Full Text of this Article]
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