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To the Editor: In their study of vitamin E on lipid peroxidation, Dr Meagher and colleagues¹ did not follow up their subjects long enough to find an effect. Peroxidation activity, or any other activity of fat-soluable vitamins, would most likely take much longer than 8 weeks to occur given their route of absorption and distribution in the body. This study would have been much more valid if it were conducted for 6- to 18-months, as is typical for lipid-lowering agents.

Jerome A. Dixon, DO,MNS
Family Physician
Campbellsville, Ky

1. Meagher EA, Barry OP, Lawson JA, et al. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA. 2001;285:1178-1182. FREE FULL TEXT

To the Editor: Dr Meagher and colleagues¹ found that vitamin E supplementation had no effect on measures of lipid peroxidation in healthy individuals, and thus questioned the rationale for this intervention. However, Stephens et al,² whom they cite, comment, "We believe that the inhibition of oxidation is likely to exert its main effects by modification of plaque enlargement or rupture" and also . . . [Full Text of this Article]

RELATED ARTICLE

Effects of Vitamin E on Lipid Peroxidation in Healthy Persons
Emma A. Meagher, Orla P. Barry, John A. Lawson, Joshua Rokach, and Garret A. FitzGerald
JAMA. 2001;285(9):1178-1182.
ABSTRACT | FULL TEXT