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To the Editor: Prior studies have indicated a possible role for in utero or early postnatal causes of acute lymphoblastic leukemia in children.^1-4 If such causes include seasonally prevalent infectious agents, then temporal patterns of birth month of affected children or the month of onset of leukemia should be expected to vary accordingly. However, studies of this issue have been generally too small to determine trends.We report the seasonal pattern in birth month and month of diagnosis for children with leukemia in the population of Denmark.

Methods

We obtained data from the Danish Cancer Registry, which was started in 1943 and which has almost complete reporting of incident cancers in Denmark. The Cancer Registry receives notifications of malignant and related diseases from hospital departments at the time of diagnosis and is notified if changes in the initial diagnosis occur. We studied the pattern of annual cyclic variation in birth month and . . . [Full Text of this Article]

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