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Mutation in the SPINK1 Trypsin Inhibitor Gene, Alcohol Use, and Chronic Pancreatitis
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To the Editor: In industrialized countries, chronic pancreatitis (CP) is caused by long-term alcohol abuse in about 70% of cases, whereas the cause is generally unknown in the other 30% of patients. Furthermore, it is unclear how alcohol use may lead to CP, and wide variation exists among individuals in their susceptibility to alcoholic CP (ACP). Only a minority of frequent drinkers develop ACP.1 However, genetic factors may also affect the pathogenesis of ACP.
Recently, an N34S mutation in the pancreatic secretory serine protease inhibitor Kazal type 1 (SPINK1) gene was found in 18 of 96 patients with idiopathic or hereditary CP.2 Therefore, in such patients with ACP, a prominent pathogenic role of trypsin activity in the pancreatic acinar cell may be suspected.
Methods
We investigated the frequency of the N34S mutation of SPINK1 in 274 patients with ACP who were admitted to 1 of our 6 institutions between . . . [Full Text of this Article]
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