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Vasilios Papademetriou, MD

JAMA. 2001;285:2774-2776.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Hypertension is a major contributor to cardiovascular morbidity and mortality in industrialized countries. During the last 3 decades, multiple prospective randomized trials, reported individually or in meta-analyses,¹ demonstrated a dramatic reduction of vascular events attributable to hypertension. At the same time, however, the incidence of end-stage renal disease (ESRD) and congestive heart failure (CHF) has steadily increased.^2-3 African Americans are particularly affected by these trends, since they have a higher prevalence and exhibit more severe forms of hypertension, resulting in higher rates of vascular complications. In particular, ESRD attributable to hypertension has increased at a rate that is several-fold higher among African American patients than white patients.⁴ Although tight blood pressure control is known to be a crucial factor in preventing progression of renal disease, other factors are undoubtedly involved. The potential renal protective effect of specific pharmacologic therapy has been addressed in only a few studies. . . . [Full Text of this Article]

Author Affiliation: Department of Cardiology, Veterans Affairs Medical Center, Washington, DC.

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JAMA. 2001;285(21):2719-2728.
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