This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in JAMA  Topic Collections  • Aging/ Geriatrics  • Oncology  • Breast Cancer  • Rheumatology  • Osteoporosis  • Women's Health  • Women's Health, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

From the Roll of the Dice to the Hand Women Were Dealt

Katrina Armstrong, MD,MSc

JAMA. 2001;285:2907-2909.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1866, French physician Paul Broca reported 10 cases of breast cancer in 4 generations of his wife's family.¹ Despite the potential of this historic observation, the next 120 years brought more frustration than progress in the assessment of breast cancer risk. The increasing appreciation of the complex and multifactorial etiology of breast cancer, the inability to identify modifiable breast cancer risk factors, the lack of effective breast cancer prevention, and the national focus on population-based breast cancer screening all contributed to the pervasive "half-empty" view of breast cancer risk prediction. A 1991 internal medicine textbook introduced the section on breast cancer risk with the statement "an inappropriate emphasis on risk factors may obscure the fact that 70 to 80 percent of all breast cancers occur in patients without identifiable risk factors."² For patients and physicians alike, breast cancer risk was seen as a roll of the . . . [Full Text of this Article]

Author Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Association Between the T29C Polymorphism in the Transforming Growth Factor 1 Gene and Breast Cancer Among Elderly White Women: The Study of Osteoporotic Fractures
Elad Ziv, Jane Cauley, Phillip A. Morin, Robert Saiz, and Warren S. Browner
JAMA. 2001;285(22):2859-2863.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Genetic Polymorphisms in the TGF-{beta}1 Gene and Breast Cancer Survival: A Report from the Shanghai Breast Cancer Study
Shu et al.
Cancer Res. 2004;64:836-839.
ABSTRACT | FULL TEXT  

Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk
Rylander-Rudqvist et al.
Carcinogenesis 2003;24:1533-1539.
ABSTRACT | FULL TEXT  

Genetic Testing
Burke
NEJM 2002;347:1867-1875.
FULL TEXT