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To the Editor: In their review of studies on the effects of hormone replacement therapy (HRT) on cognitive function in postmenopausal women, Dr LeBlanc and colleagues¹ concluded that HRT may improve specific aspects of cognitive functioning in women with menopausal symptoms (eg, hot flashes, sleep loss) but not in women who are asymptomatic. We do not believe that this conclusion is justified by the literature.

LeBlanc et al stated that in all 5 randomized controlled trials in which the women had somatic complaints, HRT improved at least 1 cognitive function, whereas no enhancement of cognitive function was found in the 2 randomized trials that studied asymptomatic women. However, these latter 2 studies did not use cognitive test measures that were found in other studies to be sensitive to the effects of HRT. One study only used a working memory measure, and the other only used the digit span and digit . . . [Full Text of this Article]

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