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Physiological Neuroimaging: Emerging Clinical Applications
Colin P. Derdeyn, MD
JAMA. 2001;285:3065-3068.
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Physiological imaging tools have provided a window for the study of central nervous system physiology and pathophysiology in living humans, particularly in the areas of cerebral ischemia and cognitive neuroscience. The first studies in living humans were performed nearly 50 years ago and involved measurements of whole brain blood flow using radiotracers.1 It is now possible to measure many dynamic physiological processes within small regions of the brain. These processes include blood flow, oxygen and glucose metabolism, electrical activity, nuclear magnetic spectra, and neurotransmitter receptor sites.
Currently, most clinical neuroimaging examinations use x-ray computed tomography and magnetic resonance (MR) methods to identify structural or anatomical abnormalities. Blood, gray matter, white matter, and spinal fluid are distinguished by differences in attenuation of the x-ray beam or by differences in their response to radiofrequency pulses, respectively. Physiological imaging techniques, in contrast, create images that show a physiological process, . . . [Full Text of this Article] Acute Ischemic Stroke
Author Affiliation: Cerebrovascular Section, NeuroImaging Laboratory and Interventional Neuroradiology Service, Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo.
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