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To the Editor: Dr Rodriguez and colleagues¹ found a direct association between the use of hormone replacement therapy (HRT) and the risk of ovarian cancer. Data from other cohort and case-control studies, however, are less consistent.²

To further explore this issue, we updated the analysis of a collaborative reanalysis of European case-control studies of ovarian cancer.³ The present analysis study included 2501 women with histologically confirmed epithelial ovarian cancer and 5882 controls enrolled in 5 case-control studies: 2 were conducted in Greece, 1 in the United Kingdom, and 1 in Italy between 1979 and 1991, all previously reported,³ plus another case-control study conducted in 4 Italian locations between 1992 and 1999.⁴

The 5 original datasets were combined in a uniform format that included comparable variables, such as age, socioeconomic level, parity, oral contraceptive use, menopausal status, type of menopause, age at menopause, as well as HRT use, duration of use, . . . [Full Text of this Article]

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