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To the Editor: Increased commercialization and competition in clinical research has led to difficulties in enrolling human subjects in a timely manner to satisfy sponsors.¹ As a result, clinical trials increasingly recruit participants outside the traditional clinic- or hospital-based settings. Investigators often advertise via radio or newspapers and promise payment for participation. These new approaches have the potential to recruit large numbers of participants to central locations and to allow faster subject accrual.

Methods

Family Health International has begun to use recent technological advances, such as interactive voice response systems (IRVSs) and the Internet, to explore the impact on data quality of more commercialized methods of recruiting subjects for clinical research. We initiated a randomized controlled trial of 2 approved barrier methods to further characterize their contraceptive effectiveness. Subjects were offered $150 for participating in the trial. To increase speed of recruitment, we advertised in 5 metropolitan newspapers and enrolled participants . . . [Full Text of this Article]

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