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To the Editor: Children who survive meningococcal septic shock syndrome (MSSS) may have long-term lung damage secondary to mechanical ventilation or to the disease itself. We studied the long-term pulmonary sequelae of MSSS and their relationship with several clinical variables during the acute phase of the disease.

Methods

We measured lung function parameters (forced expiratory volume in 1 second, forced vital capacity, total lung capacity, residual volume, and diffusing capacity of carbon monoxide) and transcutaneous arterial oxygen saturation (SaO₂) during maximal exercise in 18 children an average of 3.4 years (range, 2.2-4.9 years) after receiving mechanical ventilation for MSSS. Median age at the acute phase of disease was 4.7 years (range, 1.6-15.4 years).

Results
At follow-up, all children had normal lung function parameters and SaO₂ values at rest. During maximal exercise, the median decrease in SaO₂ was 2.5% (range, 0%-20%). In 6 children (desaturation group), SaO₂ dropped below 95% (median . . . [Full Text of this Article]

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