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Choice of Comparison Group in Assessing the Health Effects of Moderate Alcohol Consumption
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To the Editor: Prospective studies have shown that moderate alcohol drinkers have lower all-cause mortality than nondrinkers.1 Subjects in the nondrinkers category generally comprise both never drinkers and ex-drinkers. Although ex-drinkers might have quit drinking due to ill health and have higher mortality than never drinkers, many studies fail to consider them separately.1 We examined the effect of combining and separating the 2 groups on the relationship between moderate drinking and total mortality.
Methods
Subjects were 25 279 men aged 40 to 64 years who were residents of 14 municipalities in Miyagi Prefecture in northern Japan.2 During June through August 1990, self-administered questionnaires were delivered to and collected at the subjects' residences. Usable questionnaires were returned from 22 836 subjects (90.3%). The questionnaire asked subjects if they were never, ex-, or current drinkers. Current drinkers were further asked about drinking frequency, beverage types usually consumed, and amount consumed on a single occasion. From . . . [Full Text of this Article]
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