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Brian Vastag

JAMA. 2001;286:1438-1440.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Washington—Sheep cloner Ian Wilmut, PhD, of the Roslin Institute in Scotland, recently said that for human cloning to succeed, "we need a step as big as the one that produced Dolly" (see accompanying story).

If that step ever comes, it will likely involve the nascent field of epigenetics, literally, "after genetics." With the Human Genome Project nearing completion, scientists at the edge of biology are surveying enigmatic cellular processes that are perhaps as fundamental to life as DNA itself.

Although many of the estimated 40 000 genes have been spelled out to the last A, C, T, or G, researchers have only a shaky understanding of how and why they switch on and off. Thanks to microarray analysis, they know that patterns of gene expression shift like the colors of a kaleidoscope. The spiraling hues depend on where the cell lies in time—developmentally or per the . . . [Full Text of this Article]

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Mitotic errors in chromosome 21 of human preimplantation embryos are associated with non-viability
Katz-Jaffe et al.
Mol Hum Reprod 2004;10:143-147.
ABSTRACT | FULL TEXT