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Relationship Between Apolipoprotein E 4 and Sleep-Disordered Breathing at Different Ages

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To the Editor: Dr Kadotani and colleagues¹ reported an association between apolipoprotein E 4 (which is coded by the ApoE 4 allele) and sleep-disordered breathing (SDB) in a study of 791 adults, aged 32 to 68 years, in Wisconsin. We examined this association among 718 Japanese-American men, aged 79 to 97 years, who were evaluated for SDB as part of a recent follow-up examination of participants in the Honolulu-Asia Aging Study of dementia that began in 1991 (previously unpublished data).

Only 18% of our sample had the ApoE 4 allele (compared with 28% in the study by Kadotani et al¹) and consistent with other studies, these men were at increased risk for Alzheimer disease (AD).^2-3 In contrast, moderate to severe SDB (apnea-hypopnea index of >15) was common in our sample (42%) compared with the 8% prevalence in the younger cohort of Kadotani et al. After adjusting for age, body . . . [Full Text of this Article]

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