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Relationship Between Estrogen-Receptor Genotype and Tooth Loss in Postmenopausal Women
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To the Editor: Although tooth loss among elderly patients is known to be influenced by environmental factors, the role of genetic factors is largely unknown. A study of US patients, for instance, found some genetic contribution to the height of alveolar bone that supports the teeth.1 It is likely that the estrogen-receptor (ER) gene could be associated with tooth loss in women because recent studies2-3 suggest that the long-term estrogen replacement therapy (ERT) may protect against tooth loss in elderly women. We investigated the effect of ER genotype on tooth loss and alveolar height in Japanese women.
Methods
Of 531 women who visited our clinic for bone mineral density assessment between 1996 to 2001, 132 postmenopausal women (mean [SD] age, 55.3 [7.3] years) were randomly recruited for this study. Sixteen of the patients had received ERT for 6 months or less, and 1 had received it for 4 years. No patients . . . [Full Text of this Article]
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