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Francis S. Collins, MD, PhD; Alan E. Guttmacher, MD

JAMA. 2001;286:2322-2324.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Queried at the turn of the millennium about the relevance of genetic diseases to medicine, a primary care physician might well have replied "not in my practice." After all, for most of its history, medical genetics has been devoted largely to the study of relatively rare single-gene or chromosomal disorders. Patients with these disorders were mostly cared for in tertiary care medical centers by specialists. But all that is changing. As demonstrated by the collection of articles in this theme issue of THE JOURNAL, genetics is invading the mainstream of medical practice.

Of course, the human gene pool has not changed perceptibly, and the existence of hereditary contributions to most disorders has been apparent for a long time. But, other than underscoring the need for obtaining detailed family history information, many practitioners may have considered the genetic contribution to common illness . . . [Full Text of this Article]

Author Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Md.

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