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Guidelines for Diagnosis and Treatment of High Cholesterol
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To the Editor: The guidelines of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel [ATP] III)1 are too complex for use in primary care. It will be the rare family physician who takes time to figure out a Framingham Risk Score.
It is well known that low-density lipoprotein cholesterol (LDL-C) is atherogenic and that high-density lipoprotein cholesterol (HDL-C) is antiatherogenic, so combining LDL and HDL into a fraction, such as the cholesterol retention fraction (CRF, defined as [LDL-HDL]/LDL), gives a measure of the atherogenic-antiatherogenic balance. A higher systolic blood pressure (SBP) also conveys risk. Cigarette smoking may well be the most important risk factor for atherothrombotic disease.2 Plotting CRF and SBP (Figure 1), a threshold line can be drawn with defining loci (CRF = 0.74, SBP = 100; and CRF = 0.49, SBP = . . . [Full Text of this Article]
RELATED ARTICLE
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
JAMA. 2001;285(19):2486-2497.
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