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To the Editor: Dr Strom and colleagues¹ found no differences in later pubertal maturation or growth between infants who had been fed soy-based vs milk-based formula. However, this does not prove that soy-based formulas are safe. In fact, the authors found that infants who had been given soy-based formula later used more asthma and allergy medications (P = .047 and .08 for female and male subjects, respectively). This important observation was not mentioned in the abstract, which stated that "[n]o statistically significant differences were observed . . . for more than 30 outcomes."¹

This conclusion contradicts the findings of both human and animal studies. A retrospective epidemiological study by Fort et al² found that children with autoimmune disease were significantly more likely to have received soy formula as infants than were healthy siblings or control subjects. A recent study from the National Toxicology Program found that rats receiving dietary . . . [Full Text of this Article]

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