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Antioxidants and Zinc to Prevent Progression of Age-Related Macular Degeneration
Commentary by Lee M. Jampol, MD;
Frederick L. Ferris III, MD
JAMA. 2001;286(19):2466-2468.
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ARCHIVES OF OPHTHALMOLOGY
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8
Age-Related Eye Disease Study Research Group
Background Observational and experimental data suggest that antioxidant and/or zinc supplements may delay progression of age-related macular degeneration (AMD) and vision loss.
Objective To evaluate the effect of high-dose vitamins C and E, beta carotene, and zinc supplements on AMD progression and visual acuity.
Design The Age-Related Eye Disease Study, an 11-center double-masked clinical trial, enrolled participants in an AMD trial if they had extensive small drusen, intermediate drusen, large drusen, noncentral geographic atrophy, or pigment abnormalities in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye. At least 1 eye had best-corrected visual acuity . . . [Full Text of this Article]
Commentary
Author Affiliations: Department of Ophthalmology, Northwestern University Medical School, Chicago, Ill (Dr Jampol); and National Eye Institute, Bethesda, Md (Dr Ferris).
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