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To the Editor: Hyperglycemia has been associated with the atypical antipsychotic agents clozapine and olanzapine,¹ and a recent case report described diabetic ketoacidosis associated with olanzapine in a pediatric patient.² To gain further insight into the association between hyperglycemia and these 2 drugs in the pediatric population, we queried the US Food and Drug Administration (FDA) MedWatch drug surveillance system to identify cases occurring in patients younger than 19 years.

Olanzapine-Associated Cases

Between January 1996 and May 2001, the FDA received 9 spontaneous-adverse-event reports of hyperglycemia in adolescents who were aged 13 to 18 years (4 males and 5 females) and received olanzapine in daily doses of 10 to 20 mg. Seven presented with newly diagnosed hyperglycemia and 2 had exacerbation of preexisting diabetes. Presentation occurred within 1 week of drug initiation for 2 patients and within 6 months for 6 others. Glycemic control improved in 4 patients after olanzapine was discontinued . . . [Full Text of this Article]

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