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To the Editor: We agree with Mr Folkers and Dr Fauci that the success of acquired immunodeficiency syndrome research over the last 2 decades shows what can be achieved if enough financial and human resources are provided.¹ There was serious commitment from Western governments as well as major investments from the pharmaceutical industry that anticipated a hugely profitable market in developed countries.

But many infectious diseases that continue to be the leading cause of death in poor countries do not affect industrialized countries. Without enlightened self-interest by Western governments and a profitable market for industry, drug development has ground to a virtual standstill²: only 1% of the 1393 new drugs approved between 1975 and 1999 are for tropical diseases,³ which account for almost 10% of the global disease burden. Exacerbating this neglect, drug resistance is reducing the effectiveness of many available drugs.

Recently, the Drugs for Neglected Disease Working . . . [Full Text of this Article]

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The AIDS Research Model: Implications for Other Infectious Diseases of Global Health Importance
Gregory K. Folkers and Anthony S. Fauci
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