This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Mike Mitka

JAMA. 2001;286:3071.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Cyclooxygenase 2–specific (COX-2) inhibitors, widely prescribed for arthritis symptoms, may impair ligament healing associated with sprains, report researchers at the University of North Carolina at Chapel Hill School of Medicine. Unlike earlier generations of nonsteroidal anti-inflammatory drugs, which have been found to promote ligament healing, the COX-2 inhibitors apparently do not, said Lawrence E. Dahners, MD, professor of orthopedics.

The study in rats involved an experimental model for an acute injury of the medial collateral ligament, in humans the most common site of knee sprains. Postoperatively, half the animals were given the COX-2 inhibitor celecoxib for the first 6 days of recovery and half were not treated. About 2 weeks later, the injured and uninjured ligaments were tested for healing strength. Celecoxib decreased ligament healing strength by 32%, the researchers said.

They cautioned that the findings are preliminary and call for further study to determine the long-term effects . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?