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Statins and Fracture Risk
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To the Editor: Dr van Staa and colleagues1 concluded that "use of statins . . . was not associated with a reduction in risk of fracture." This conclusion is contrary to the results of our study2 as well as others.3-4 Our results, like those of van Staa et al, were derived from the General Practice Research Database (GPRD). However, the study by van Staa et al encompassed 683 practices originally considered to have data of satisfactory quality; by contrast, the Boston Collaborative Drug Surveillance Program conducts ongoing internal (unpublished) validation studies to identify practices that provide unsatisfactory data. As a result, several practices were excluded and our recent study encompassed only 340 practices. Van Staa et al also failed to exclude patients at high risk for fracture, for instance patients with osteoporosis, osteomalacia, cancer, alcoholism, and those receiving bisphosphonates. We excluded such patients since it is well recognized that including . . . [Full Text of this Article]
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