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Association Between Bone Mineral Density and Serum Lipids in Men
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To the Editor: An association between statin use and decreased fracture risk has been postulated from the results of 3 case-control studies.1-3 However, other results4 have not supported these conclusions and prospective studies5-6 found no evidence of an effect of statins on fracture risk. It is possible that some of the earlier positive results resulted from unmeasured confounding.
Methods
From the data set of an ongoing longitudinal study of the incidence and genetic transmission of osteoporosis among healthy men aged 40 to 70 years in our Health District,7 we examined the relationship between lipid profile and bone mineral density (QDR 4500, Hologic Inc, Bedford, Mass) at the spine, femoral neck, and total hip. Individuals with conditions known to interfere with bone metabolism were excluded, as were those receiving statins or other lipid-lowering agents. Overall, the study sample included 427 healthy men. In some of them the dual-energy x-ray absorptiometry measurements could . . . [Full Text of this Article]
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