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Diabetes Mellitus—A Call for Papers
David S. Cooper, MD;
Catherine D. DeAngelis, MD,MPH
JAMA. 2001;286:968-969.
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For patients with diabetes, and for those who treat or study the disease, the last decade has been one of great progress and promise. Tremendous advances have been made in understanding the pathogenesis of both type 1 and type 2 diabetes. The Diabetes Control and Complications Trial (DCCT), published in 19931 and the United Kingdom Prospective Diabetes Study (UKPDS), published in 1998,2 provided indisputable evidence that near-normal blood glucose levels are desirable for almost all patients with diabetes.
New therapies for type 2 diabetes have been introduced that enhance insulin release and insulin sensitivity, alter hepatic glucose output, and interfere with intestinal absorption of glucose.3 New routes of insulin delivery, including inhaled and oral insulins, may make therapy more acceptable to patients.4 Modifications of the insulin molecule should enhance the ability to control glucose levels while minimizing the risks of hypoglycemia.5 Implantable . . . [Full Text of this Article]
Author Affiliations: Dr DeAngelis is Editor and Dr Cooper is a Contributing Editor, JAMA.
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