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Joan Stephenson, PhD

JAMA. 2002;287:1255.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

One of the big question marks hovering over cloning research is whether the technique has any long-term adverse effects. Now, a new study by Japanese investigators—the first to track cloned mammals from birth to death—has found that mice cloned from somatic cells have a significantly shorter life span than those conceived in the usual way.

Researchers at the National Institute of Infectious Diseases in Tokyo and colleagues examined 12 male mice that had been cloned from immature cells in the testis and compared them with 13 control male mice. Half of the control mice were the product of natural mating; the others were derived from spermatid injection (injecting a sperm nucleus into a recipient egg to mimic the cloning technique).

The cloned mice began to die after only 311 days, and 10 of the 12 died before 800 days. Only three of the 13 control mice died . . . [Full Text of this Article]

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