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Poliomyelitis and Parkinson Disease
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To the Editor: Parkinson disease (PD), which is due to loss of dopaminergic neurons in the zona compacta of the substantia nigra,1 may involve both genetic and environmental risk factors.2 Poliovirus is believed to cause neuronal damage in the substantia nigra,3 and thus a history of poliovirus infection may be associated with an increased risk of PD.4
Methods
We assessed the risk of PD in a large cohort of patients hospitalized for poliomyelitis in Copenhagen, Denmark, between 1919 and 1954.5 This cohort represented more than 80% of all the cases of poliomyelitis registered by the National Board of Health in the population of Copenhagen during the same period.5 A total of 5421 of these patients were alive on January 1, 1977, when the National Hospital Discharge Register (NHDR) was established in Denmark. The NHDR is a population-based register containing information on all somatic hospitalizations and, since January 1, 1995, all outpatient . . . [Full Text of this Article]
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ABSTRACT
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