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Brian Vastag

JAMA. 2002;287:1923-1924.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Bethesda, Md—Falling in line with the evidence-based medicine trend, an international team of women's health experts is discouraging the use of hormone replacement therapy (HRT) for many postmenopausal conditions. Coronary heart disease, fractures, depression, urinary incontinence—all cited in the past as prime reasons to initiate HRT—are losing favor as valid indications for it, as evidence from high-quality clinical trials accumulates.

In 1992, three major organizations threw their collective weight behind guidelines that pushed physicians to prescribe HRT for women with or at risk of heart disease and osteoporosis. Endorsed by the American College of Physicians, the American College of Family Medicine, and the US Preventive Services Task Force, the guidelines relied almost exclusively on soft data from observational studies and clinical experience.

A decade later, those recommendations seem quaint. At a symposium sponsored by the Office of Women's Health Research at the National Institutes of Health (NIH) . . . [Full Text of this Article]

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ABSTRACT