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-Methylacyl Coenzyme A Racemase as a Marker for Prostate Cancer

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To the Editor: Dr Rubin and colleagues suggested that -methylacyl coenzyme A racemase (AMACR) may be a tissue biomarker for prostate cancer.¹ We agree that AMACR is a promising diagnostic marker for prostate cancer and recently reported that AMACR has high sensitivity for the detection of prostate cancer on needle biopsy.² However, it is important to recognize the limitations of this marker. In our study of atypical adenomatous hyperplasia of the prostate, a benign condition that mimics prostate cancer, AMACR immunoreactivity was found in a small subset of cases (17.5%).³ Therefore, caution should be exercised in interpretation of AMACR immunostaining.

Zhong Jiang, MD; Bruce A. Woda, MD
Department of Pathology
University of Massachusetts Medical School
Worcester

Ximing J. Yang, MD,PhD
Departments of Pathology and Surgery
University of Chicago
Chicago, Ill

1. Rubin MA, Zhou M, Dhanasekaran SM, et al. -Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. JAMA. 2002;287:1662-1670. FREE FULL TEXT 2. Jiang Z, Woda BA, Rock KL, et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol. 2001;25:1397-1404. FULL TEXT | ISI | PUBMED 3. Yang XJ, Wu CL, Woda BA, et al. Expression of -methylacyl CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am J Surg Pathol. In press.

In Reply: In response to Dr Jiang and colleagues, 3 independent groups have now reported that AMACR is expressed in . . . [Full Text of this Article]

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