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Postmenopausal Hormone Therapy and Quality of Life
No Cause for Celebration
Kathryn M. Rexrode, MD,MPH;
JoAnn E. Manson, MD,DrPH
JAMA. 2002;287:641-642.
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Despite the common perception that postmenopausal hormone therapy improves quality of life in women, few randomized clinical trials have addressed this issue. Moreover, the high rates of discontinuation of hormone therapy in the first few years of use in both observational studies1-2 and randomized trials3 cast doubt on this assumption. The study by Hlatky et al4 in this issue of THE JOURNAL presents important and intriguing data regarding hormone therapy and quality of life that were previously lacking. This report is particularly informative because the investigators stratify their results according to the presence or absence of vasomotor flushing symptoms at baseline.
Hlatky et al compared the effect of hormone therapy vs placebo on quality-of-life parameters among women in the Heart Estrogen/Progestin Replacement Study (HERS) trial, a randomized clinical trial of combined conjugated equine estrogens and medroxyprogesterone acetate among women with pre-existing coronary . . . [Full Text of this Article]
Author Affiliations: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston Mass.
RELATED ARTICLE
Quality-of-Life and Depressive Symptoms in Postmenopausal Women After Receiving Hormone Therapy: Results From the Heart and Estrogen/Progestin Replacement Study (HERS) Trial
Mark A. Hlatky, Derek Boothroyd, Eric Vittinghoff, Penny Sharp, Mary A. Whooley, and for the HERS Research Group
JAMA. 2002;287(5):591-597.
ABSTRACT
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