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Safe Sex for Men With Coronary Artery Disease
Exercise, Sildenafil, and Risk of Cardiac Events
Thomas H. Marwick, MD,PhD
JAMA. 2002;287:766-767.
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Sildenafil has been in widespread use for 3 years, but concerns persist regarding its safety in patients with a history of cardiac disease. Major adverse effects, including myocardial infarction and death, have been recorded in case reports and postmarketing surveillance.1 However, questions have been raised regarding the accuracy of these reports, the potential for reporting bias, and whether the number of reported events exceeds that expected in a population of this age.2 The central issue is to what extent these adverse events reflect a risk from the drug and to what extent they reflect the risks of physical activity in patients with coronary artery disease.
The study by Arruda-Olson and colleagues3 in this issue of THE JOURNAL suggests that the cardiovascular effects of sildenafil are limited, even in patients with coronary artery disease. In an elegant study using a crossover design, the authors evaluated 105 men . . . [Full Text of this Article]
Author Affiliation: University of Queensland, Brisbane, Australia.
RELATED ARTICLE
Cardiovascular Effects of Sildenafil During Exercise in Men With Known or Probable Coronary Artery Disease: A Randomized Crossover Trial
Adelaide M. Arruda-Olson, Douglas W. Mahoney, Ajay Nehra, Marilyn Leckel, and Patricia A. Pellikka
JAMA. 2002;287(6):719-725.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Tharyan
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Sildenafil and Cardiac Function During Exercise
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