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Joan Stephenson, PhD

JAMA. 2002;287:828.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Chicago—The abrupt onset of obsessive-compulsive disorder (OCD) and tic disorders in children appears to be linked in some cases to acute streptococcal infections and may respond to prompt treatment with antibiotics, according to findings presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy.

Previous research had linked a sudden appearance of neuropsychiatric symptoms (such as obsessions, compulsions, and motor or vocal tics, alone or in combination) following a strep throat infection caused by group A -hemolytic Streptococcus (GABHS)—an association known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS.

The new work, which is the first study to identify children at the onset of a first episode of PANDAS and follow them prospectively, confirms the association of such symptoms and acute GABHS tonsillopharyngitis and demonstrates that the symptoms may respond to appropriate antibiotic treatment, said Michael Pichichero, MD, of the University of Rochester . . . [Full Text of this Article]

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