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To the Editor: Popular wisdom holds that not getting enough sleep increases the propensity of catching a cold or other ailments. In America, sleep duration has steadily declined from nearly 9 hours in 1960 to less than 7 hours currently.^1-2 Although adverse effects of sleep deprivation on immune parameters have been documented,³ the clinical implications of these findings are unclear. We examined the effect of sleep deprivation on immune response to influenza vaccination.

Methods

Subjects were 25 healthy young men (mean age, 23 years) who consented to participate in a protocol approved by our institutional review board. Eligibility criteria included bedtime between 11 PM and 1 AM, waking time between 7 and 9 AM, and time in bed of 7.5 to 8.5 hours. None of the subjects had been immunized against influenza during the preceding 3 years. Eleven subjects had their bedtime restricted to 4 hours (1-5 AM) for 6 nights . . . [Full Text of this Article]

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