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Guidelines for Treatment of Anthrax
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To the Editor: We wish to provide the following factual corrections in response to the article by Dr Inglesby and colleagues1 about anthrax as a biological weapon.
First, Inglesby et al state that there are no US Food and Drug Administration (FDA)approved postexposure antibiotic regimens following exposure to a Bacillus anthracis aerosol. In fact, on August 30, 2000, the FDA approved ciprofloxacin for use in inhalational anthrax (postexposure) for both adults and children. (Inhalational anthrax postexposure is also referred to as anthrax postexposure prophylaxis [PEP].)
Second, the FDA and its Anti-infectives Advisory Committee have stated that the risk-benefit assessment for use of ciprofloxacin for inhalational anthrax PEP is such that it is presently recommended for use in children.2 The members of the agency believe clinicians should be informed that ciprofloxacin is approved by the FDA for pediatric use in inhalational anthrax PEP. Specifically, the ciprofloxacin label states:
Safety and effectiveness . . . [Full Text of this Article]
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Anthrax as a Biological Weapon, 2002: Updated Recommendations for Management
Thomas V. Inglesby, Tara O'Toole, Donald A. Henderson, John G. Bartlett, Michael S. Ascher, Edward Eitzen, Arthur M. Friedlander, Julie Gerberding, Jerome Hauer, James Hughes, Joseph McDade, Michael T. Osterholm, Gerald Parker, Trish M. Perl, Philip K. Russell, Kevin Tonat, and for the Working Group on Civilian Biodefense
JAMA. 2002;287(17):2236-2252.
ABSTRACT
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