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To the Editor: Oxidative stress may be involved in the pathogenesis of both Alzheimer disease (AD) and vascular dementia (VaD).¹ A controlled trial of vitamin E supplementation among patients with AD found delayed time to institutionalization, but no specific effect on cognitive function.² Observational studies have found vitamin E and vitamin C to be protective against both AD^3-4 and VaD.⁵

There are few prospective studies, however, of the association between use of antioxidant supplements and incident dementia. In a previous analysis from the Honolulu-Asia Aging Study (HAAS), the use of both vitamins E and C 4 years prior to diagnosis was associated with a reduced risk for VaD; no association with AD was observed.⁵ These analyses were based on prevalent cases of dementia. Herein we examine the relationship between the intake of supplemental vitamins E and C and the risk for subtypes of incident dementia.

Methods

The HAAS is a population-based . . . [Full Text of this Article]

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