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  Vol. 288 No. 20, November 27, 2002 TABLE OF CONTENTS
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PET Theory Applied to Stroke Prevention

Mike Mitka

JAMA. 2002;288:2531.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Many physicians in the 1970s believed carotid artery bypass surgery provided benefit to patients at risk of having a first or recurrent stroke. But a large international clinical trial discredited the theory, and the procedure essentially disappeared from operating rooms in the United States.

Today some researchers think they have the imaging technology to identify a subset of patients with stroke whose response to medical treatment—anticoagulants or antiplatelet agents—is poor (subsequent stroke rate of 25% to 50% within 2 years) and who may benefit from bypass surgery.

William J. Powers, MD, a professor in the departments of neurology and radiology at Washington University School of Medicine in St Louis, and his colleagues have begun the Carotid Occlusive Surgery Study (COSS)—a $20-million randomized multicenter trial funded by the National Institute of Neurological Disorders and Stroke. The study is also being conducted by researchers at the University of Iowa.

The . . . [Full Text of this Article]







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